Peptide Database

Peptide NameSLAY-screened peptide P4764

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H156N28O28S

DescriptionStandard

        HLPGLNFDWHNLFLPYNTPC
    

Molecular Weight2398.69 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-1.08

Net Charge (pH 7.4) -1.40

Charge Density (pH 7.0) -0.0538

GRAVY Index-0.26

Hydrophobic Moment 0.23

Boman Index0.24

Instability Index43.08

Aliphatic Index 78.00

Aromaticity 0.2000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 870.03

LogP -4.56

H-bond Donors 28.0

H-bond Acceptors 30.0

Rotatable Bonds 66.0

Heavy Atoms 171.0

Ring Count 10.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0235936 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/