Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length532 amino acids

Chemical FormulaC2585H4086N682O764S17

DescriptionStandard

        MSGAGGRWKGPVGGRAVSESVNKRHNVPPQFHFLVQFHSCAAVSEPLSLGSVSGVSSAPQCRGLNLQADTPSYKMKLWVPLVLLVCGATKCEEPGIKGRLTLKGLHYGWQVVLEEVQRRLSSLQIPDVSGSVSVPVLGAIYYSVSSLQIQELDLSHSDASFSSDTGLKVSVSDGRTRVTGYIEIRTVLFGTSSSLEVSVDGLSLSAVLGLTRDDAGRGALWNAGCSSSVGQVDLNFHGGSGWILSMFKGSMLGPIHDAFSQQLCPQFDRSVVQMETLLSSLPVTEPVDSVAALELSLVSPPLITEQNVDLLVRGQFVGLSQRWDVPYSPVEMDLPDAESRMLVLAVSQFSANSASYVHYKSGALRANITDDMIPKESPLRLNTKSFAAFAPELPNRFPGSPPLLLQLSAPSPPEVTCQTDLLTLGASLDIQLSALYPESPPAPAFQLQAVDELQHMMSFALKVIGFPLLNKKLQKVFPIPTPLVRLQSPTVRVFQGFLLVVSDLEIDPWTQYQKVSDVAWEIPKTHKPSPFL
    

Molecular Weight57487.31 Da

Isoelectric Point (pI)5.84

Net Charge (pH 7.0)-6.64

Net Charge (pH 7.4) -7.56

Charge Density (pH 7.0) -0.0125

GRAVY Index0.08

Hydrophobic Moment 0.63

Boman Index0.13

Instability Index53.61

Aliphatic Index 98.14

Aromaticity 0.0733

Extinction Coeff. Reduced 58900.00

Extinction Coeff. Oxidized 59275.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0343065 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence