Peptide Database

Peptide NameSLAY-screened peptide P5735

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC111H158N24O28S

DescriptionStandard

        PLTYAPFVVINSPWSCLHTY
    

Molecular Weight2308.65 Da

Isoelectric Point (pI)7.11

Net Charge (pH 7.0)0.03

Net Charge (pH 7.4) -0.09

Charge Density (pH 7.0) 0.0017

GRAVY Index0.48

Hydrophobic Moment 0.36

Boman Index0.39

Instability Index83.29

Aliphatic Index 92.50

Aromaticity 0.2000

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 793.59

LogP -4.10

H-bond Donors 29.0

H-bond Acceptors 30.0

Rotatable Bonds 62.0

Heavy Atoms 164.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0283681 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/