Peptide Database

Peptide NameSLAY-screened peptide P1352

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC84H131N27O27S

DescriptionStandard

        APGRPRPAEPSNNAYSAPM
    

Molecular Weight1983.17 Da

Isoelectric Point (pI)8.79

Net Charge (pH 7.0)0.80

Net Charge (pH 7.4) 0.61

Charge Density (pH 7.0) 0.0420

GRAVY Index-1.14

Hydrophobic Moment 0.40

Boman Index-0.17

Instability Index72.49

Aliphatic Index 21.05

Aromaticity 0.0526

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 851.14

LogP -11.81

H-bond Donors 27.0

H-bond Acceptors 29.0

Rotatable Bonds 54.0

Heavy Atoms 139.0

Ring Count 6.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0317544 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/