Peptide Database

Peptide NameCholecystokinin-25

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC130H197N37O40S2

DescriptionStandard

        IKNLQSLDPSHRISDRDYMGWMDFG
    

Molecular Weight2982.31 Da

Isoelectric Point (pI)5.36

Net Charge (pH 7.0)-1.15

Net Charge (pH 7.4) -1.41

Charge Density (pH 7.0) -0.0460

GRAVY Index-0.84

Hydrophobic Moment 0.56

Boman Index-0.13

Instability Index70.48

Aliphatic Index 62.40

Aromaticity 0.1200

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1263.52

LogP -11.95

H-bond Donors 44.0

H-bond Acceptors 42.0

Rotatable Bonds 98.0

Heavy Atoms 209.0

Ring Count 6.0

Amide Bonds 26.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0094974 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCholecystokinin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods18:Sulfotyrosine; 24:Phenylalanine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

Half-LifeMammalian: 20 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0201782 VERIFIED: YES

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCholecystokinin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods18:Sulfotyrosine; 24:Phenylalanine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 20 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0277968 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyGastrin/cholecystokinin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsTyr18 Sulfotyrosine; Phe24 Amidation

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide