Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2336H3724N588O673S20

DescriptionStandard

        MSPCCWLALLALVPFALATNPGVKVKLTEKGIEYGKQIGMASLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGITIVNLGLPYSALALVPDTGISLSITNAFISLHGNWKIRYLSFIKDSGSFDLEVNGLTVTDSITIKSDETGRPTVSSVNCVANVGSASIKFHGGASWLYNLFSVYVDKALRSALQKQICPLVADTITDMNPHLKTLNVLAKVDKYAEVEYSMVTSPTISNASIDFSLKGEFYNIGKHQEPPFSPTPFSLPHQVNNMLYIGMSAFTTNSAGFVYNNAGALSLYITDDMIPPSSPIRLNTRTFGAFIPEIAKRFPSMMMKLLVKTVKEPTIFFEPNNVTVQASGSVTAYAIQPNTTLSPLFVLNMEGSVSARLYVTGVKLAGAVTLNKIEMTLETSYVGQFQVRSLDNIFLMVLKVAVIPKVNARLEKGFPLPSIGKMNLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight51455.39 Da

Isoelectric Point (pI)9.14

Net Charge (pH 7.0)8.91

Net Charge (pH 7.4) 8.28

Charge Density (pH 7.0) 0.0188

GRAVY Index0.20

Hydrophobic Moment 0.68

Boman Index0.17

Instability Index28.58

Aliphatic Index 100.13

Aromaticity 0.0867

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40590.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0132155 VERIFIED: YES

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyBPI/LBP

Tax ID8022

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria