Peptide Database

Peptide NameSLAY-screened peptide P5260

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC122H169N27O27S2

DescriptionStandard

        GLYIHVPHDMYPLYKCHYIF
    

Molecular Weight2509.94 Da

Isoelectric Point (pI)7.01

Net Charge (pH 7.0)0.01

Net Charge (pH 7.4) -0.37

Charge Density (pH 7.0) 0.0004

GRAVY Index0.11

Hydrophobic Moment 0.38

Boman Index0.31

Instability Index81.58

Aliphatic Index 92.50

Aromaticity 0.2500

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 828.92

LogP 0.31

H-bond Donors 29.0

H-bond Acceptors 32.0

Rotatable Bonds 72.0

Heavy Atoms 178.0

Ring Count 10.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0328856 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/