MYP_169449
Atr-AMP1
Antimicrobial
Standard
14 amino acids
C72H119N23O17S3
Standard
MLCPSYRRCPRVPP
1675.05 Da
9.69
2.48
2.23
0.1771
-0.51
0.66
-0.26
101.52
48.57
0.0714
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
632.62
-5.23
24.0
23.0
46.0
115.0
5.0
13.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0226545
VERIFIED: YES
Provenance & Taxonomy
Amaranthus tricolor [Plant]
PrAMP
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
3-9
APD analysis reveals that this sequence is most similar (47%) to Metalnikowin I. Chemical modification: There are extensive post-translational modifications: M is oxidized, A single hydroxylation at P4, P13 or P14 (Proline: 29%), and C3-C9 forms a S-S bond. This is the first proline-rich AMP with a disulfide bond. Further styudies are needed to elucidate additional residues that might be oxidized or hydroxylated (i.e., P, Y), at least one arginine. Warning: there may be other modifications such as D-amino acids since the synthetic forms were inactive
Bio-Activity Profile
Antimicrobial
Gram+ (e.g. Staphylococcus aureus LAC)