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MYP_169393
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Basic Information
AC-UM-14W (De novo synthesis)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C71H124N22O16
Standard
Sequence
KAAKAAKKAAKAAWK
Physicochemical Analysis
1541.88 Da
10.70
5.75
5.54
0.3836
-0.66
0.70
-0.22
9.33
53.33
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
642.63
-5.16
23.0
22.0
55.0
109.0
2.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0217250 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
200 μg/mL
MIC
PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
RECORD: Rec_0219417 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Hemolytic
human red blood cells
12.5 μM
Hemolysis
PaperThuy T T Dinh, Do-Hee Kim, Huy X Luong, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. Epub 2015 Jun 19. PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
RECORD: Rec_0224885 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial
Pseudomonas aeruginosa ATCC 27853
200 μM
MIC
PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
RECORD: Rec_0253958 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 2 ,6, 9 and 13) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (2) and Ⓧ (6), Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis ATCC 6633
1.6 μM
MIC
PaperThuy T T Dinh, Do-Hee Kim, Huy X Luong, Bong-Jin Lee, Young-Woo Kim. Antimicrobial activity of doubly-stapled alanine/lysine-based peptides. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4016-9. Epub 2015 Jun 19. PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
RECORD: Rec_0266287 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
12.5-25 μM
Hemolysis
PMID26235946 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26235946/
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