Peptide Database

Peptide NameBMAP-18

Function Ontology

Anticancer

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC113H188N34O20

DescriptionStandard

        GRFKRFRKKFKKLFKKIS
    

Molecular Weight2342.92 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)9.75

Net Charge (pH 7.4) 9.54

Charge Density (pH 7.0) 0.5418

GRAVY Index-1.25

Hydrophobic Moment 0.83

Boman Index-0.59

Instability Index-6.93

Aliphatic Index 43.33

Aromaticity 0.2222

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 946.09

LogP -4.98

H-bond Donors 36.0

H-bond Acceptors 30.0

Rotatable Bonds 88.0

Heavy Atoms 167.0

Ring Count 4.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0343992 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHuman immunodeficiency virus 1 (HIV-1)

Activity0.35 μM

MethodEC50

RECORD: Rec_0382321 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral Cytotoxic

PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. Antimicrob Agents Chemother. 2008 Sep;52(9):3438-3440. doi: 10.1128/AAC.00452-08. PMID: 18591279. PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/

RECORD: Rec_0386183 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1IIIB | CEM-SS cells

Activity0.35 μM

MethodEC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperAnti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins. | Wang G, Watson KM, Buckheit RW Jr. | Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. | DOI:10.1128/AAC.00452-08 | PMID:18591279 PMID18591279 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18591279/

RECORD: Rec_0407717 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic Cytotoxic

TargetCEM-SS cells

Activity8.45 μM

MethodCC50

RECORD: Rec_0413480 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Bos taurus [Animal]

FamilyCathelicidin

Tax ID9606,9913

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Multifunction

TargetCEM-SS

Activity0.35 μM

MethodIC50

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