Peptide Database

Peptide NameGastrin-releasing peptide

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length27 amino acids

Chemical FormulaC125H198N40O32S2

DescriptionStandard

        APVTAGRAGALAKMYTRGNHWAVGHLM
    

Molecular Weight2837.29 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)2.97

Net Charge (pH 7.4) 2.68

Charge Density (pH 7.0) 0.1099

GRAVY Index0.04

Hydrophobic Moment 0.47

Boman Index0.15

Instability Index19.24

Aliphatic Index 72.59

Aromaticity 0.0741

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1137.88

LogP -11.04

H-bond Donors 41.0

H-bond Acceptors 39.0

Rotatable Bonds 88.0

Heavy Atoms 199.0

Ring Count 6.0

Amide Bonds 27.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0044441 VERIFIED: NO

Provenance & Taxonomy

OrganismOvis aries [Animal]

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone

RECORD: Rec_0178370 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0298132 VERIFIED: YES

Provenance & Taxonomy

OrganismOvis aries [Animal]

FamilyGastrin-releasing peptide

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Growth regulation Development regulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0389406 VERIFIED: NO

Provenance & Taxonomy

OrganismOvis aries [Animal]

FamilyBombesin/neuromedin-B/ranatensin

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide Hormone