Peptide Database

Peptide NameNatriuretic peptide DNP-2

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC185H296N58O53S2

DescriptionStandard

        EVKYDPCFGHKIDRINHVSNLGCPSLRDPRPTAPAALR
    

Molecular Weight4244.82 Da

Isoelectric Point (pI)8.87

Net Charge (pH 7.0)1.99

Net Charge (pH 7.4) 1.69

Charge Density (pH 7.0) 0.0524

GRAVY Index-0.62

Hydrophobic Moment 0.54

Boman Index-0.15

Instability Index48.73

Aliphatic Index 74.47

Aromaticity 0.0526

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1769.37

LogP -18.57

H-bond Donors 62.0

H-bond Acceptors 59.0

Rotatable Bonds 132.0

Heavy Atoms 298.0

Ring Count 9.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0419558 VERIFIED: NO

Provenance & Taxonomy

OrganismDendroaspis angusticeps [Animal]

FamilyNatriuretic peptide DNP

Tax ID8618

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-23

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour