Peptide Database

Peptide NameT-111

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC178H279N47O58

DescriptionStandard

        LVFPSDEFDASISQVNEKINQSLAFIRKSDELLHN
    

Molecular Weight4005.40 Da

Isoelectric Point (pI)4.58

Net Charge (pH 7.0)-3.14

Net Charge (pH 7.4) -3.41

Charge Density (pH 7.0) -0.0898

GRAVY Index-0.30

Hydrophobic Moment 0.63

Boman Index-0.01

Instability Index42.33

Aliphatic Index 100.29

Aromaticity 0.0857

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1726.95

LogP -17.59

H-bond Donors 57.0

H-bond Acceptors 56.0

Rotatable Bonds 136.0

Heavy Atoms 283.0

Ring Count 5.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0400556 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-RSV Entry inhibition

TargetRespiratory syncytial virus (RSV) | HEp-2 cells

Activity2.247 μM

MethodEC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2186-91. | DOI:10.1073/pnas.93.5.2186 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

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