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MYP_169276
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Basic Information
Cyclotide vibi-H (Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C142H235N35O42S6
Standard
Sequence
GLLPCAESCVYIPCLTTVIGCSCKSKVCYKN
Physicochemical Analysis
3296.98 Da
8.32
1.70
1.40
0.0548
0.67
0.33
0.21
35.95
94.19
0.0645
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1218.80
-12.22
48.0
50.0
104.0
225.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0315548 VERIFIED: NO
Provenance & Taxonomy
Viola biflora [Plant]
Cyclotide
214529
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
disulfide-stabilized; exact pairings not extracted
cystine-knot scaffold
Bio-Activity Profile
Anticancer Antimicrobial
PaperPlant Antimicrobial Oligopeptides with Anticancer Properties as a Source of Biologically Active Peptides—An In Silico Study PMID41009751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/41009751/
RECORD: Rec_0346798 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0359884 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperThe alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity.
RECORD: Rec_0402065 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0409192 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
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