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MYP_169214
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
33 amino acids
C153H247N47O43S6
Standard
Sequence
ACGILHDNCVYVPAQNPCCRGLQCRYGKCLVQV
Physicochemical Analysis
3625.28 Da
8.35
1.82
1.49
0.0552
0.22
0.47
0.06
30.49
88.48
0.0606
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1448.65
-15.21
54.0
52.0
114.0
249.0
5.0
37.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0193618 VERIFIED: YES
Provenance & Taxonomy
Trinnidad chevron tarantula [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic
PaperIsolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei.
RECORD: Rec_0196263 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiparasitic Antiplasmodial
Human erythrocytes
10 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/15304333/ PMID15304333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15304333/
RECORD: Rec_0241827 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0250610 VERIFIED: YES
Provenance & Taxonomy
Psalmopoeus cambridgei [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antiplasmodial Cytotoxic
Plasmodium falciparum
1.59 μM
IC50
PaperPubMed PMID: 15304333 | PubMed PMID: 16452619 PMID15304333;16452619 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15304333/
RECORD: Rec_0307809 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Psalmopeotoxin I
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
2-19, 9-24, 18-29
Bio-Activity Profile
Antimicrobial Antimalarial Antiparasitic
Plasmodium falciparum columbian FcB1
1.59±1.15 μM
IC50; [3H] Hypoxanthine incorporation assay
PMID15304333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15304333/
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