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MYP_169133
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Basic Information
Unnamed
Anticancer
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging
Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-wrinkle
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
5 amino acids
C26H42N8O8
Standard
Sequence
YIGSR
Physicochemical Analysis
594.66 Da
8.75
0.76
0.55
0.1518
-0.50
0.49
-0.12
46.52
78.00
0.2000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
282.08
-2.78
11.0
9.0
18.0
42.0
1.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0050125 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Pentapeptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-aging Anti-wrinkle Wound healing
Human skin fibroblasts (Hs27) (In vitro)
Cell viability assay; Cytotoxicity assay
PaperPatent US 9999649 B2 PatentUS 9999649 B2
RECORD: Rec_0135475 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
PEGylation
None
Bio-Activity Profile
Anti-metastatic
0.15 μM
Radioactivity measured with a gamma counter
Intravenous injection of labelled peptide in C57BL/6 mice, in vivo; 150 s
PMID10544005 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10544005/
RECORD: Rec_0147178 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperYamamoto S., Kaneda Y., Okada N., Nakagawa S., Kubo K., Inoue S., Maeda M., Yamashiro Y.. Antimetastatic effects of synthetic peptides containing the core sequence of the type III connecting segment domain (IIICS). Anti-Cancer Drugs, 5, 424-428, 1994.
RECORD: Rec_0155538 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Toxic
PaperChambers B. J., Klein N. W., Conrad S. H., Ruppenthal G. C., Sackett G. P., Weeks B. S., Kleinman H. K.. Reproduction and sera embryotoxicity after immunization of monkeys with the laminin peptides YIGSR, RGD and IKVAV. Proc. Natl Acad Sci. USA, 92, 6818-6822, 1995.
RECORD: Rec_0164511 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anti-metastatic
1.5 μM
Radioactivity measured with a gamma counter
Intravenous injection of labelled peptide in C57BL/6 mice, in vivo; <60 s
PMID10544005 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10544005/
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