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MYP_169037
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Basic Information
Viscotoxin-A2 (VtA2; Plant defensin)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
46 amino acids
C199H323N61O67S6
Standard
Sequence
KSCCPNTTGRNIYNTCRFGGGSREVCASLSGCKIISASTCPSYPDK
Physicochemical Analysis
4834.45 Da
8.90
3.70
3.40
0.0804
-0.38
0.64
-0.08
43.03
44.57
0.0652
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2077.07
-31.90
80.0
77.0
155.0
333.0
6.0
48.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0169109 VERIFIED: YES
Provenance & Taxonomy
Viscum album [Plant]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Cytotoxic
PaperPubMed PMID: 4607177 | PubMed PMID: 12733989 PMID4607177;12733989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4607177/
RECORD: Rec_0230791 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 45.7%, E 13.0%, T 23.9%, C 17.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0316905 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperSchrader G., Apel K.;. Isolation and characterization of cDNAs encoding viscotoxins of mistletoe (Viscum album)."; Eur. J. Biochem. 198:549-553. Evidence URLhttps://www.uniprot.org/uniprotkb/THN2_VISAL/entry
RECORD: Rec_0384395 VERIFIED: NO
Provenance & Taxonomy
Viscum album [Plant]
Thionin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperViscotoxin-A2 Evidence URLhttps://www.uniprot.org/uniprotkb/P32880/entry
RECORD: Rec_0399003 VERIFIED: YES
Provenance & Taxonomy
Viscum album [Plant]
Thionin
3972
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Toxin
PaperPubMed PMID 4607177 | PubMed PMID 5035954 | PubMed PMID 4000000 PMID4607177;5035954;4000000;503595;44000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4607177/
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