Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length180 amino acids

Chemical FormulaC909H1441N247O247S7

DescriptionStandard

        PKTLPVAHEPMLMLALTDFVANSAAFTYFTAGALRRNISSNMIPQQFSLQLKTKNIGVFSPQLQEHYPDLPMELHLWARQQPLLSCHTDALHGTLFSSAEAFVVLPNTTRIPVFLLNIDANVTGKPTITRNRLRGTVRLTGSLPALCWAQGLTVPQVKRLETLLKFGLWLFGVPRANSEC
    

Molecular Weight20006.13 Da

Isoelectric Point (pI)9.67

Net Charge (pH 7.0)6.38

Net Charge (pH 7.4) 6.00

Charge Density (pH 7.0) 0.0354

GRAVY Index0.09

Hydrophobic Moment 0.56

Boman Index0.12

Instability Index55.55

Aliphatic Index 99.72

Aromaticity 0.0833

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7824.91

LogP -86.88

H-bond Donors 271.0

H-bond Acceptors 265.0

Rotatable Bonds 641.0

Heavy Atoms 1410.0

Ring Count 37.0

Amide Bonds 197.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0137046 VERIFIED: NO

Provenance & Taxonomy

OrganismPitta sordida [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria