Peptide Database

Peptide NameNeuroendocrine regulatory peptide-1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Hormonal / Endocrine ▸ Secretory pathway peptide ▸ Secretory granule peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length26 amino acids

Chemical FormulaC113H191N35O40

DescriptionStandard

        RPESALLGGSEAGERLLQQGLAQVEA
    

Molecular Weight2679.94 Da

Isoelectric Point (pI)4.49

Net Charge (pH 7.0)-2.23

Net Charge (pH 7.4) -2.44

Charge Density (pH 7.0) -0.0857

GRAVY Index-0.30

Hydrophobic Moment 0.60

Boman Index-0.00

Instability Index57.42

Aliphatic Index 101.54

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1224.76

LogP -14.72

H-bond Donors 41.0

H-bond Acceptors 38.0

Rotatable Bonds 92.0

Heavy Atoms 188.0

Ring Count 1.0

Amide Bonds 28.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0433541 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyNeuroendocrine regulatory peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsC-terminal amidation

Bio-Activity Profile

Function

Vasopressin release inhibition Body fluid homeostasis Hormone Endocrine Neuropeptide Neuromodulator

TargetRat hypothalamic paraventricular and supraoptic nuclei; vasopressin secretion

MethodIn vitro hypothalamic vasopressin secretion assay

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