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MYP_168992
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Basic Information
Brevinin-1ITa
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C105H183N23O22S3
Standard
Sequence
IVPFLLGMVPKLVCLITKKC
Physicochemical Analysis
2215.91 Da
9.39
2.74
2.50
0.1369
1.52
0.54
0.44
39.53
160.50
0.0500
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
696.93
0.12
25.0
28.0
72.0
153.0
3.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0267832 VERIFIED: NO
Provenance & Taxonomy
Rana italica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID28699258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28699258/
RECORD: Rec_0279317 VERIFIED: YES
Provenance & Taxonomy
Rana italica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Antifungal Anti-Gram-negative Anti-Gram-positive Cytolytic Cytotoxic Hemolytic
S. epidermidis (Gram-positive)
PMID28699258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28699258/
RECORD: Rec_0372032 VERIFIED: YES
Provenance & Taxonomy
skin secretions of the Italian stream frog Rana italica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MDA-MB-231
8 μM
LC50
PaperPubMed PMID: 28699258 PMID28699258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28699258/
RECORD: Rec_0388947 VERIFIED: YES
Provenance & Taxonomy
skin secretions of the Italian stream frog Rana italica [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
mouse erythrocytes
7 μM
LC50
PaperPubMed PMID: 28699258 PMID28699258 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28699258/
RECORD: Rec_0393837 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
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