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MYP_168847
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
20 amino acids
C91H164N22O22
Standard
Sequence
LIGPVLGLVGSALGGLLKKI
Physicochemical Analysis
1918.41 Da
10.00
1.76
1.55
0.0879
1.49
0.49
0.56
12.56
190.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
679.70
-2.78
23.0
24.0
65.0
135.0
1.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0227915 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
Bombinin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID8223491 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8223491/
RECORD: Rec_0228042 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus Cowan 1
PMID8223491 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8223491/
RECORD: Rec_0235844 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antiparasitic
C. jeikeium ATCC BAA-949
8 μM
MIC
PaperAntibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata
RECORD: Rec_0251992 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 20.0%, E 0.0%, T 50.0%, C 30.0% [Linear]
D-residue-containing modified peptide [Mixed]
None
Amidation
D-alloisoleucine at position 2
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Anti-Gram-positive Cytotoxic Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0262929 VERIFIED: YES
Provenance & Taxonomy
Bombina variegata [Animal]
Bombinin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
PaperM. Simmaco et al. / Biochimica et Biophysica Acta 1788 (2009) 1551-1555. Bombinins, antimicrobial peptides from Bombina species Evidence URLhttps://www.uniprot.org/uniprotkb/P82284/entry
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