Peptide Database

Peptide NameSLAY-screened peptide P451

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC92H143N29O26S2

DescriptionStandard

        RPNWNIRSCIQCEFQIQ
    

Molecular Weight2135.43 Da

Isoelectric Point (pI)8.07

Net Charge (pH 7.0)0.74

Net Charge (pH 7.4) 0.51

Charge Density (pH 7.0) 0.0437

GRAVY Index-0.71

Hydrophobic Moment 0.45

Boman Index-0.19

Instability Index88.34

Aliphatic Index 68.82

Aromaticity 0.1176

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 932.70

LogP -9.44

H-bond Donors 33.0

H-bond Acceptors 29.0

Rotatable Bonds 69.0

Heavy Atoms 149.0

Ring Count 4.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0175541 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/