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MYP_168808
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Basic Information
Hp1404-T1d
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C68H131N17O14
Standard
Sequence
ILKKLLKKVKSI
Physicochemical Analysis
1410.87 Da
10.60
4.76
4.54
0.3963
0.36
0.75
-0.06
-5.48
186.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
533.75
-0.75
19.0
19.0
55.0
99.0
0.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0045523 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ranacyclin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Pseudomonas aeruginosa 431
3.13 μM
MIC
PMID29379033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29379033/
RECORD: Rec_0047280 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ranacyclin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Pseudomonas aeruginosa 434
3.13 μM
MIC
PMID29379033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29379033/
RECORD: Rec_0061417 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ranacyclin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Pseudomonas aeruginosa 3904
6.25 μM
MIC
PMID29379033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29379033/
RECORD: Rec_0071670 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Pseudomonas aeruginosa 3904
6.25 μM
MIC
PaperMechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa. Sci Rep. 2018 Jan 29;8(1):1763. doi: 10.1038/s41598-018-19434-7. PMID: 29379033. PMID29379033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29379033/
RECORD: Rec_0072442 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Ranacyclin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Pseudomonas aeruginosa 559
12.5 μM
MIC
PMID29379033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29379033/
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