Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length523 amino acids

Chemical FormulaC2707H4198N714O756S24

DescriptionStandard

        MMARPYCVLVVLLLMVEATRFGEGTSNPGFVARITRKGFEYARQYGIATLKKKLSTLEIPDFSGRFRAEWLGEVSYEFYSLWISNFKLRNSDLQLLPKHGIRASLSNNYVFVHGKWNVKKYFISLRGNFDLKIDGASIVLSVNLGKDASGRPTAYVSQCNNSIGSVNINISGHLSWILNLFHERIERNFKNIMEQKICENIRQMASSHLDPYLQTLPVAVRIDKVSGIDYSLIEAPQVTSQSLDAHFKGEFFELSRHSSAPFDAPPFVLPQENDHMVYSAISEYFFNTASWVYHNTGLMNFTIQNKQLGELTKLANTPSAKRWRKQYMNPGCQTSKSLTSCLISGFLLCLMQIPLDSNIQLNTNSFRPVIPQLTRMYPNMELEFEVSPESAPLLMFTPGNVTFMPVMNAWLFVLLPNSSEREPVCQFRVSTNISATITINAYRVFGSVSTVSKLKLELKHSKIGFFKVELMEHFLHYFAMHTIFPSLNAKLEEGFLLPLPRDISLNNWNLQVHKEQAMVLEKS
    

Molecular Weight59610.18 Da

Isoelectric Point (pI)9.03

Net Charge (pH 7.0)9.71

Net Charge (pH 7.4) 8.55

Charge Density (pH 7.0) 0.0186

GRAVY Index-0.09

Hydrophobic Moment 0.85

Boman Index0.08

Instability Index38.16

Aliphatic Index 90.57

Aromaticity 0.1128

Extinction Coeff. Reduced 69330.00

Extinction Coeff. Oxidized 69705.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0035940 VERIFIED: NO

Provenance & Taxonomy

OrganismErinaceus europaeus [Animal]

FamilyBPI/LBP

Tax ID9365

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria