Peptide Database

Peptide NameSecretogranin-1

Function Ontology

Hormonal / Endocrine ▸ Secretory pathway peptide ▸ Secretory granule peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length657 amino acids

Chemical FormulaC3241H4992N996O1131S10

DescriptionStandard

        MPVDNRNHNEGMVTRCIIEVLSNALSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEAGAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQREDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQEESEEGEEDATSEVDKRRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRASEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRVQENQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSSHHTAEKRKRLGELFNPYYDPLQWKSSHFERRDNMNDNFLEGEEENELTLNEKNFFPEYNYDWWEKKPFSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFYDSEEPVSTHQEAENEKDRADQTVLTEDEKKELENLAAMDLELQKIAEKFSQRG
    

Molecular Weight76324.96 Da

Isoelectric Point (pI)5.02

Net Charge (pH 7.0)-50.86

Net Charge (pH 7.4) -52.80

Charge Density (pH 7.0) -0.0774

GRAVY Index-1.64

Hydrophobic Moment 0.74

Boman Index-0.38

Instability Index66.04

Aliphatic Index 38.95

Aromaticity 0.0685

Extinction Coeff. Reduced 86290.00

Extinction Coeff. Oxidized 86415.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0419837 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyChromogranin/secretogranin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsThr59 Phosphothreonine; Ser79 Phosphoserine; Ser80 Phosphoserine; Ser129 Phosphoserine; Ser163 Phosphoserine; Ser239 Phosphoserine; Ser243 Phosphoserine; Ser273 Phosphoserine; Ser274 Phosphoserine; Ser291 Phosphoserine; Ser315 Phosphoserine; Tyr321 Sulfotyrosine; Ser357 Phosphoserine; Ser360 Phosphoserine; Ser385 Phosphoserine; Tyr451 Sulfotyrosine; Tyr454 Sulfotyrosine; Ser513 Phosphoserine; Ser514 Phosphoserine; Tyr546 Sulfotyrosine; Tyr548 Sulfotyrosine; Ser597 Phosphoserine; Tyr604 Sulfotyrosine; Ser606 Phosphoserine; Ser611 Phosphoserine

Bio-Activity Profile

Function

Secretory granule peptide Neuropeptide precursor