Peptide Database

Peptide NameSLAY-screened peptide P1374

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC89H128N20O25S2

DescriptionStandard

        CDFRMPTYKYNYDII
    

Molecular Weight1942.22 Da

Isoelectric Point (pI)5.95

Net Charge (pH 7.0)-0.25

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0168

GRAVY Index-0.59

Hydrophobic Moment 0.26

Boman Index-0.06

Instability Index62.23

Aliphatic Index 52.00

Aromaticity 0.2667

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 748.46

LogP -3.85

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 59.0

Heavy Atoms 136.0

Ring Count 5.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0251905 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/