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MYP_168729
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Basic Information
MERS-LP
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Standard
36 amino acids
C185H307N43O61S
Standard
Sequence
SLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKEL
Physicochemical Analysis
4141.73 Da
4.18
-3.53
-3.75
-0.0981
0.13
0.61
0.12
17.68
138.06
0.0556
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1717.88
-14.30
58.0
59.0
143.0
290.0
2.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0252151 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
HR2-derived fusion inhibitor
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012
13.9 μM
IC50
PaperStructure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor PMID24473083 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24473083/
RECORD: Rec_0258742 VERIFIED: YES
Provenance & Taxonomy
Tylonycteris bat coronavirus HKU4 [Virus]
HR2-derived fusion inhibitor
694007
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus
1.71 μM
IC50
PaperPotent MERS-CoV fusion inhibitory peptides identified from HR2 domain in spike protein of bat coronavirus HKU4 PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
RECORD: Rec_0261558 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
PEG8-K(Chol)
PEG8-K(Chol)
Bio-Activity Profile
Antiviral Fusion inhibition
inhibition of pseudovirus infection in Huh-7 cells
25 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperSARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. | Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y. | Signal Transduct Target Ther. 2021 Aug 3;6(1):294. | DOI:10.1038/s41392-021-00698-x | PMID:34344868 PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/
RECORD: Rec_0277416 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus [Virus]
Synthetic antiviral peptide
1335626
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2 S943P
1 μM
IC90
PaperInhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the SARS-CoV-2 spike glycoprotein HRC domain PMID33082259 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33082259/
RECORD: Rec_0287984 VERIFIED: YES
Provenance & Taxonomy
Tylonycteris bat coronavirus HKU4 [Virus]
HR2-derived fusion inhibitor
694007
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus
1.31 μM
IC50
PaperPotent MERS-CoV fusion inhibitory peptides identified from HR2 domain in spike protein of bat coronavirus HKU4 PMID30646495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30646495/
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