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MYP_168729
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Basic Information
MERS-LP
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Standard
36 amino acids
C185H307N43O61S
Standard
Sequence
SLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKEL
Physicochemical Analysis
4141.73 Da
4.18
-3.53
-3.75
-0.0981
0.13
0.61
0.12
17.68
138.06
0.0556
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1717.88
-14.30
58.0
59.0
143.0
290.0
2.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0223674 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus [Virus]
Synthetic antiviral peptide
1335626
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2 S943P
1 μM
IC50
PaperInhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the SARS-CoV-2 spike glycoprotein HRC domain PMID33082259 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33082259/
RECORD: Rec_0234424 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus [Virus]
Synthetic antiviral peptide
1335626
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2 D614G
1 μM
IC90
PaperInhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the SARS-CoV-2 spike glycoprotein HRC domain PMID33082259 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33082259/
RECORD: Rec_0238388 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
PEG8-K(Chol)
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion
0.0791±0.0098 μM
IC50
PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/
RECORD: Rec_0246417 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus isolate United Kingdom,H123990006,2012 [Virus]
HR2-derived fusion inhibitor
1263720
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Middle East respiratory syndrome-related coronavirus isolate United Kingdom/H123990006/2012
0.93 μM
IC50
PaperStructure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor PMID24473083 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24473083/
RECORD: Rec_0250731 VERIFIED: YES
Provenance & Taxonomy
Middle East respiratory syndrome-related coronavirus [Virus]
Synthetic antiviral peptide
1335626
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
0.7 μM
IC90
PaperInhibition of coronavirus entry in vitro and ex vivo by a lipid-conjugated peptide derived from the SARS-CoV-2 spike glycoprotein HRC domain PMID33082259 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33082259/
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