Peptide Database

Peptide NameSLAY-screened peptide P2362

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC112H185N39O28

DescriptionStandard

        ILRRRRTRHHSYVVITLSFD
    

Molecular Weight2525.91 Da

Isoelectric Point (pI)11.83

Net Charge (pH 7.0)3.94

Net Charge (pH 7.4) 3.63

Charge Density (pH 7.0) 0.1969

GRAVY Index-0.45

Hydrophobic Moment 0.40

Boman Index-0.32

Instability Index130.48

Aliphatic Index 107.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1121.53

LogP -10.23

H-bond Donors 44.0

H-bond Acceptors 34.0

Rotatable Bonds 83.0

Heavy Atoms 179.0

Ring Count 4.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0298938 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/