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MYP_168590
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Basic Information
Taromycin A
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
13 amino acids
C61H84N16O25
Standard
Sequence
WNDTGKDADGAEY
Physicochemical Analysis
1441.41 Da
4.05
-3.24
-3.45
-0.2489
-1.65
0.39
-0.19
-18.96
15.38
0.1538
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
687.08
-8.14
23.0
22.0
45.0
102.0
3.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018106 VERIFIED: YES
Provenance & Taxonomy
Bacteria [Bacterium]
2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID24826994 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24826994/
RECORD: Rec_0073062 VERIFIED: YES
Provenance & Taxonomy
marine actinomycete Saccharomonospora sp. CNQ-490 [other]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Gram-positive
PaperPubMed PMID: 24449899 PMID24449899 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24449899/
RECORD: Rec_0114111 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Saccharomonospora sp [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Lipidation
Esterification
Bio-Activity Profile
Antimicrobial
Enterococcus faecalis 613D, E. faecium 447D
50 μg/mL
MIC
PaperDirect cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.
RECORD: Rec_0157010 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Saccharomonospora sp [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Lipidation
Esterification
Bio-Activity Profile
Antimicrobial
MRSA 0325
12 μg/mL
MIC
PaperDirect cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.
RECORD: Rec_0212771 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Saccharomonospora sp [Synthetic]
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Lipidation
Esterification
Bio-Activity Profile
Antimicrobial
Enterococcus faecalis 613, Enterococcus faecalis 447
6 μg/mL
MIC
PaperDirect cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.
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