Peptide Database

Peptide NameAbatacept

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Immunomodulation ▸ Immuno-oncology

Standard StatusStandard

Sequence Length329 amino acids

Chemical FormulaC1674H2641N441O504S21

DescriptionStandard

        MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREKIHIPERSDEAQRVFKSSKTSSCDKSDTCF
    

Molecular Weight37681.89 Da

Isoelectric Point (pI)6.46

Net Charge (pH 7.0)-1.86

Net Charge (pH 7.4) -2.72

Charge Density (pH 7.0) -0.0056

GRAVY Index-0.33

Hydrophobic Moment 0.61

Boman Index-0.01

Instability Index54.53

Aliphatic Index 83.19

Aromaticity 0.0851

Extinction Coeff. Reduced 40910.00

Extinction Coeff. Oxidized 41535.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0383196 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory Immuno-oncology

Half-Life16.7 (12-23) days in healthy subjects; 13.1 (8-25) days in RA subjects; 14.3 days when subcutaneously administered to adult RA patients.