Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length442 amino acids

Chemical FormulaC2222H3460N580O631S12

DescriptionStandard

        THPGFKVRITQAGLNYAREHAVAALEEELSQLRLPDISGDFRVPNVGKVYYELSSLKLRSFHLPDSSIFPVPNVGLQVTISNAFAEVDGDWRVKVYFIRDHGSFDLKVEDLYIRISLTLGSDASGKPTADASDCSTHISNIRIYFSGKFGWLYNLFHSVIESTFRRILESKVCENVVSSVHSELQPYLQTLPVTARIDAMAGIDYSLVAPPAATAQSLDADLKGEFFSLAHHSSVPFPPPPLAFPPDHDRMVYFGASSYFFNTASLVYHAAGALVFELTDSMIPKGLDFHLNTSIFSAFIPQLEKMYPDMLMKLRLSTPAAPFLSIGPEGLSLRPVVDIQAYAILPSSSLAPLFLLNMVSNVSATIDVKSGNIVGNLTVGRLRLSLKHSDVGPFQVRMLQSMMNIFASGILLPRLNDRLKQGFPLPLPDRIQLSNVILQSHQ
    

Molecular Weight48779.53 Da

Isoelectric Point (pI)6.38

Net Charge (pH 7.0)-3.36

Net Charge (pH 7.4) -4.37

Charge Density (pH 7.0) -0.0076

GRAVY Index0.11

Hydrophobic Moment 0.74

Boman Index0.14

Instability Index43.41

Aliphatic Index 100.59

Aromaticity 0.0973

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 31985.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0369828 VERIFIED: NO

Provenance & Taxonomy

OrganismStruthio camelus australis [Animal]

FamilyBPI/LBP

Tax ID441894

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria