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MYP_168469
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Basic Information
Brevinin-2GU
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C135H238N40O40S2
Standard
Sequence
GVIIDTLKGAAKTVAAELLRKAHCKLTNSC
Physicochemical Analysis
3125.71 Da
9.31
2.83
2.54
0.0942
0.30
0.55
0.07
2.78
114.00
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1300.49
-13.64
48.0
46.0
108.0
217.0
1.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0212369 VERIFIED: YES
Provenance & Taxonomy
Hylarana guntheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
24-30
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
64 μM
MIC
PaperA Potent, Non-Toxic Insulin-Releasing Peptide Isolated From an Extract of the Skin of the Asian Frog, Hylarana Guntheri (Anura:Ranidae)
RECORD: Rec_0216784 VERIFIED: YES
Provenance & Taxonomy
Hylarana guntheri [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPubMed PMID: 19332309 PMID19332309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19332309/
RECORD: Rec_0249978 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
P. acnes strain 15725
25 μM
MIC
PMID22374306 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22374306/
RECORD: Rec_0260769 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
64.0 μM
MIC
PaperJ.M. Conlon et al. / Regulatory Peptides 151 (2008) 153-159. A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae)
RECORD: Rec_0311689 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
P. acnes strain 18380
12.5 μM
MIC
PMID22374306 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22374306/
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