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MYP_168469
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Basic Information
Brevinin-2GU
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C135H238N40O40S2
Standard
Sequence
GVIIDTLKGAAKTVAAELLRKAHCKLTNSC
Physicochemical Analysis
3125.71 Da
9.31
2.83
2.54
0.0942
0.30
0.55
0.07
2.78
114.00
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1300.49
-13.64
48.0
46.0
108.0
217.0
1.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160661 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
24-30
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
700.0 μM
HC50
PaperJ.M. Conlon et al. / Regulatory Peptides 151 (2008) 153-159. A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae)
RECORD: Rec_0162158 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
P. acnes strain 33257
6 μM
MIC
PMID22374306 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22374306/
RECORD: Rec_0172810 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Propionibacterium acnes ATCC 11828
12.5 μM
MIC
PMID22374306 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22374306/
RECORD: Rec_0198521 VERIFIED: NO
Provenance & Taxonomy
Rana guentheri,Hylarana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0206049 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 36.7%, E 0.0%, T 40.0%, C 23.3% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Toxic Hemolytic Cytotoxic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
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