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MYP_168469
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Basic Information
Brevinin-2GU
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C135H238N40O40S2
Standard
Sequence
GVIIDTLKGAAKTVAAELLRKAHCKLTNSC
Physicochemical Analysis
3125.71 Da
9.31
2.83
2.54
0.0942
0.30
0.55
0.07
2.78
114.00
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1300.49
-13.64
48.0
46.0
108.0
217.0
1.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0020409 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
P. acnes strain 31766
6 μM
MIC
PMID22374306 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22374306/
RECORD: Rec_0041190 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
P. acnes strain 50247
6 μM
MIC
PMID22374306 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22374306/
RECORD: Rec_0066217 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
24-30
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
32.0 μM
MIC
PaperJ.M. Conlon et al. / Regulatory Peptides 151 (2008) 153-159. A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae)
RECORD: Rec_0099132 VERIFIED: YES
Provenance & Taxonomy
Hylarana guentheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
P. acnes strain 32548
25 μM
MIC
PMID22374306 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22374306/
RECORD: Rec_0150709 VERIFIED: YES
Provenance & Taxonomy
Hylarana guntheri [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
24-30
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
64 μM
MIC
PaperA Potent, Non-Toxic Insulin-Releasing Peptide Isolated From an Extract of the Skin of the Asian Frog, Hylarana Guntheri (Anura:Ranidae)
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