Peptide Database

Peptide NameSLAY-screened peptide P1717

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC100H161N27O29S

DescriptionStandard

        PGPLHATFRCPTIIIPTTTSN
    

Molecular Weight2237.58 Da

Isoelectric Point (pI)8.68

Net Charge (pH 7.0)1.04

Net Charge (pH 7.4) 0.91

Charge Density (pH 7.0) 0.0493

GRAVY Index0.10

Hydrophobic Moment 0.35

Boman Index0.20

Instability Index23.20

Aliphatic Index 79.05

Aromaticity 0.0476

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 860.01

LogP -9.95

H-bond Donors 31.0

H-bond Acceptors 32.0

Rotatable Bonds 63.0

Heavy Atoms 157.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0164242 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/