Peptide Database

Peptide NameBeta-defensin 135

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length77 amino acids

Chemical FormulaC398H645N107O100S7

DescriptionStandard

        MATRSVLLALVVLNLLFYVPPGRSGPNVYIQKIFASCWRLQGTCRPKCLKNEQYRILCDTIHLCCVNPKYLPILTGK
    

Molecular Weight8753.49 Da

Isoelectric Point (pI)9.54

Net Charge (pH 7.0)7.52

Net Charge (pH 7.4) 7.15

Charge Density (pH 7.0) 0.0977

GRAVY Index0.29

Hydrophobic Moment 0.66

Boman Index0.11

Instability Index49.80

Aliphatic Index 112.60

Aromaticity 0.0909

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11835.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3305.01

LogP -24.02

H-bond Donors 120.0

H-bond Acceptors 116.0

Rotatable Bonds 281.0

Heavy Atoms 612.0

Ring Count 15.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0109324 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KP9/entry; https://bblserver.org.in/ampdb/

RECORD: Rec_0378489 VERIFIED: NO