Peptide Database

Peptide NameNL6-3

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC66H108N16O15

DescriptionStandard

        TAYFLLKLAGRL
    

Molecular Weight1365.66 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)1.40

Net Charge (pH 7.4) 1.20

Charge Density (pH 7.0) 0.1163

GRAVY Index0.90

Hydrophobic Moment 0.52

Boman Index0.28

Instability Index-4.98

Aliphatic Index 146.67

Aromaticity 0.1667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 511.80

LogP -1.45

H-bond Donors 19.0

H-bond Acceptors 17.0

Rotatable Bonds 44.0

Heavy Atoms 97.0

Ring Count 2.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0208461 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Replication inhibition

TargetHIV-1

Activity315±30 μM

MethodIC50

Half-LifeMammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h

PaperSequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme. | Li HY, Zawahir Z, Song LD, Long YQ, Neamati N. | J Med Chem. 2006 Jul 27;49(15):4477-86. | DOI:10.1021/jm060307u | PMID:16854053 PMID16854053 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16854053/

RECORD: Rec_0393919 VERIFIED: YES