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MYP_168248
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Basic Information
Kalata-B6 (Plant defensin)
Antimicrobial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
30 amino acids
C124H192N36O42S6
Standard
Sequence
GLPVCGETCFGGTCNTPGCSCSSWPICTRN
Physicochemical Analysis
3051.46 Da
5.96
-0.30
-0.59
-0.0099
0.08
0.23
0.15
50.71
35.67
0.0667
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1223.63
-19.19
48.0
48.0
89.0
208.0
6.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0190566 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15649388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15649388/
RECORD: Rec_0283973 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0306041 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-27
Bio-Activity Profile
Insecticidal Hemolytic
PaperPubMed PMID: 17534989 PMID17534989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17534989/
RECORD: Rec_0336130 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
60225
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic
PaperStudies on the membrane interactions of the cyclotides kalata B1 and kalata B6 on model membrane systems by surface plasmon resonance.
RECORD: Rec_0368581 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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