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MYP_168240
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Basic Information
Aurein2.6
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C77H132N18O20
Standard
Sequence
GLFDIAKKVIGVIGSL
Physicochemical Analysis
1629.98 Da
8.59
0.76
0.55
0.0474
1.30
0.56
0.47
11.78
164.38
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
609.39
-2.91
21.0
21.0
56.0
115.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0155548 VERIFIED: YES
Provenance & Taxonomy
Litoria aurea; Litoria raniformis [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Anticancer
PaperRozek T., Wegener K.L., Bowie J.H., Olver I.N., Carver J.A., Wallace J.C., Tyler M.J.;. The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. Eur. J. Biochem. 267, 5330-5341, 2000. PMID10951191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10951191/
RECORD: Rec_0155686 VERIFIED: YES
Provenance & Taxonomy
Litoria raniformis [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
Breast tumor cell line
10 μM
LC50
PaperThe antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2 PMID10951191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10951191/
RECORD: Rec_0168840 VERIFIED: YES
Provenance & Taxonomy
Litoria raniformis [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Antitumor Anti-Gram-positive
L. innocua
100 μg/mL
MIC
PMID10951191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10951191/
RECORD: Rec_0178740 VERIFIED: YES
Provenance & Taxonomy
Ranoidea raniformis [Animal]
116057
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus epidermidis
50 μg/mL
MIC
PaperThe antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
RECORD: Rec_0214680 VERIFIED: YES
Provenance & Taxonomy
Litoria raniformis [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anticancer
Listeria innocua
100 μg/mL
MIC
PaperHost-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-1054. doi: 10.1016/j.peptides.2004.03.006. PMID: 15203252. PMID10951191;15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10951191/
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