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MYP_168174
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Basic Information
Hp1404
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C75H119N17O18
Standard
Sequence
GILGKLWEGVKSIF
Physicochemical Analysis
1546.85 Da
8.59
0.76
0.55
0.0544
0.67
0.56
0.39
19.71
132.14
0.1429
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
566.98
-1.48
20.0
19.0
52.0
110.0
3.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0386641 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PaperMechanisms driving the antibacterial and antibiofilm properties of Hp1404 and its analogue peptides against multidrug-resistant Pseudomonas aeruginosa. Sci Rep. 2018 Jan 29;8(1):1763. doi: 10.1038/s41598-018-19434-7. PMID: 29379033. PMID29379033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29379033/
RECORD: Rec_0389291 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
Ranacyclin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Pseudomonas aeruginosa 778
12.5 μM
MIC
PMID29379033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29379033/
RECORD: Rec_0393527 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
Ranacyclin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Mouse RBC
200 μg/mL
Hemolysis
PMID29379033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29379033/
RECORD: Rec_0401309 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
4.04 μM
MIC
RECORD: Rec_0410924 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
Ranacyclin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antibiofilm Anti-Gram-negative
Pseudomonas aeruginosa 4007
25 μM
MIC
PMID29379033 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29379033/
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