Peptide Database

Peptide NameDeca 1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC80H104N26O12

DescriptionStandard

        YRWWRWARRW
    

Molecular Weight1621.85 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.3759

GRAVY Index-2.11

Hydrophobic Moment 0.91

Boman Index-0.60

Instability Index206.18

Aliphatic Index 10.00

Aromaticity 0.5000

Extinction Coeff. Reduced 23490.00

Extinction Coeff. Oxidized 23490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 656.21

LogP -0.32

H-bond Donors 28.0

H-bond Acceptors 16.0

Rotatable Bonds 45.0

Heavy Atoms 118.0

Ring Count 9.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0200297 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHSV-1:inhibition of virus infection in NP-2/CD4/CCR5 cells

Activity20 μM

MethodIC50

RECORD: Rec_0423387 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HSV Binding inhibition

TargetHSV-1 | NP-2/CD4/CCR5 cells

Activity20 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min

PaperApolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity. | Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB. | FEBS J. 2007 Sep;274(17):4511-25. | DOI:10.1111/j.1742-4658.2007.05981.x | PMID:17681018 PMID17681018 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17681018/

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