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MYP_168147
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Basic Information
Casein alpha-s2 [205-208]
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
4 amino acids
C26H43N7O6
Standard
Sequence
VRYL
Physicochemical Analysis
549.66 Da
8.72
0.73
0.52
0.1832
0.55
0.98
-0.03
-11.35
170.00
0.2500
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
232.75
-0.23
9.0
7.0
16.0
39.0
1.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018749 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
Casein-derived peptide
9940
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
Angiotensin-I converting enzyme
24.1 μM
IC50
RECORD: Rec_0048514 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
24.1
IC50
PaperMurray B.A., FitzGerald R. J.. Angiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry, bioactivity and production. Curr. Pharm. Des., 2007, 13, 773-791.
RECORD: Rec_0126730 VERIFIED: YES
Provenance & Taxonomy
Ovis aries [Animal]
alpha-S2-Casein-derived
9940
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
24.1 μM
IC50
PaperAngiotensin converting enzyme-inhibitory activity of peptides isolated from Manchego cheese Stability under simulated gastrointestinal digestion | Gomez-Ruiz, JA. et al. | DOI: 10.1016/j.idairyj.2004.04.007 Evidence URLhttps://www.uniprot.org/uniprotkb/P04654/entry
RECORD: Rec_0145582 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 0.0%, C 100.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0184931 VERIFIED: NO
Provenance & Taxonomy
Manchego cheese [Animal]; Ovis aries [Animal]; Bos taurus [Animal]
33208; 9940; 9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperAngiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry, bioactivity and production PMID17430180 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17430180/
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