Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length196 amino acids

Chemical FormulaC994H1572N268O266S9

DescriptionStandard

        PMTLPMAHEPMLLLAVTEFVANSAAFTYFTAGALRRNISSDMLPQRFPLQLRTKSMEVFSPQLQERYPDQPMELHLWARRQPLLSCHPDALHGTLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLVPDPELAWTLLPALCRAQGLPVPQVKRLETLLKFGLWLFGVPRANSECYPIPVP
    

Molecular Weight21821.34 Da

Isoelectric Point (pI)9.28

Net Charge (pH 7.0)4.30

Net Charge (pH 7.4) 3.97

Charge Density (pH 7.0) 0.0219

GRAVY Index0.07

Hydrophobic Moment 0.54

Boman Index0.11

Instability Index58.07

Aliphatic Index 98.06

Aromaticity 0.0816

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21095.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8366.54

LogP -99.34

H-bond Donors 287.0

H-bond Acceptors 283.0

Rotatable Bonds 684.0

Heavy Atoms 1537.0

Ring Count 45.0

Amide Bonds 210.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0400792 VERIFIED: NO

Provenance & Taxonomy

OrganismTichodroma muraria [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria