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MYP_168009
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Basic Information
Com5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
6 amino acids
C49H67N17O7
Standard
Sequence
RRWWRF
Physicochemical Analysis
1006.17 Da
12.00
2.76
2.56
0.4600
-2.08
1.14
-0.80
199.27
0.00
0.5000
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
426.10
-0.70
18.0
10.0
29.0
73.0
5.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0246141 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Linear: [Escherichia coli DH5alpha
100 μM
MIC
PMID17985396 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17985396/
RECORD: Rec_0249297 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
60 μM
LD99
Human Serum: Degraded quickly with half-lifes of less than 0.5 h and are completely gone after 2 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0259324 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0275832 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
7.5 μM
LD99
Human Serum: Have half-lifes of ~1.5 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0291176 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus subtilis
7.5 μM
LD99
Human Serum: Have half-lifes of about 1 h, still almost fully degraded after 2 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
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