Peptide Database

Peptide NameSynenkephalin

Function Ontology

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Standard StatusStandard

Sequence Length69 amino acids

Chemical FormulaC317H507N91O110S6

DescriptionStandard

        DCSKDCASCALHLGQQREINSLACTLECEGKLPSAKAWGTCKELLLLTKVDNVQDGEKYQDNNDSHYAA
    

Molecular Weight7545.35 Da

Isoelectric Point (pI)4.89

Net Charge (pH 7.0)-4.11

Net Charge (pH 7.4) -4.53

Charge Density (pH 7.0) -0.0596

GRAVY Index-0.56

Hydrophobic Moment 0.57

Boman Index-0.09

Instability Index51.68

Aliphatic Index 75.07

Aromaticity 0.0435

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3281.82

LogP -39.68

H-bond Donors 116.0

H-bond Acceptors 114.0

Rotatable Bonds 257.0

Heavy Atoms 524.0

Ring Count 7.0

Amide Bonds 76.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0015145 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilySynenkephalin

Tax ID8355

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-24; 6-28; 9-41

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator

Half-LifeMammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour

RECORD: Rec_0026981 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyOpioid

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Opioid Analgesic Neuromodulator

RECORD: Rec_0303997 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/