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MYP_167953
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Basic Information
Citropin 1.1 [D4A][S11A][G14R][G15R]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C83H148N24O17
Standard
Sequence
GLFAVIKKVAAVIRRL
Physicochemical Analysis
1754.21 Da
12.00
3.76
3.55
0.2349
1.26
0.82
0.22
34.56
170.62
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
675.66
-2.46
25.0
21.0
60.0
124.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002142 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
25 μg/mL
MIC
PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0002876 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
Citropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Lung cancer group (NCI)
10 μM
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1. Eur J Biochem. 2003 Mar;270(6):1141-1153. doi: 10.1046/j.1432-1033.2003.03462.x. PMID: 12631273. PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0006042 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0059406 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 87.5%, E 0.0%, T 0.0%, C 12.5% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0060002 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pasteurella multocida
100 μg/mL
MIC
PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
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