Peptide Database

Peptide NameTemplate Beta-defensin (10-38) [C25S]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC145H231N47O34S4

DescriptionStandard

        GFCIPIRCPGHTRQIGTCFGPRVKSCRKW
    

Molecular Weight3304.94 Da

Isoelectric Point (pI)10.17

Net Charge (pH 7.0)5.81

Net Charge (pH 7.4) 5.49

Charge Density (pH 7.0) 0.2002

GRAVY Index-0.30

Hydrophobic Moment 0.40

Boman Index-0.10

Instability Index24.07

Aliphatic Index 50.34

Aromaticity 0.1034

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5750.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1299.64

LogP -12.96

H-bond Donors 51.0

H-bond Acceptors 45.0

Rotatable Bonds 103.0

Heavy Atoms 230.0

Ring Count 8.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0141443 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetEscherichia coli ML-35

Activity1 μM

MethodMIC

RECORD: Rec_0159394 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetStaphylococcus aureus 710A

Activity2 μM

MethodMIC

RECORD: Rec_0172009 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

TargetHuman erythrocytes (<10% Hemolysis at 10 microM

Activity10 μM

MethodHemolysis

RECORD: Rec_0343403 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetCandida albicans

Activity1 μM

MethodMIC

RECORD: Rec_0358341 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetPseudomonas aeruginosa ATCC 27853

Activity4 μM

MethodMIC