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MYP_167926
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Basic Information
Clavanin-A
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
23 amino acids
C131H184N34O27
Standard
Sequence
VFQFLGKIIHHVGNFVHGFSHVF
Physicochemical Analysis
2667.07 Da
8.75
1.08
0.67
0.0470
0.78
0.64
0.46
-14.16
101.30
0.2174
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
950.67
-3.94
32.0
32.0
83.0
192.0
9.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009614 VERIFIED: YES
Provenance & Taxonomy
Styela clava [Animal]
Clavanin-A
7725
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania braziliensis 2904
>100 μM
LD50; MTT assay
PMID17888907 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17888907/
RECORD: Rec_0067194 VERIFIED: YES
Provenance & Taxonomy
Styela clava [Animal]
Clavanin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Candida albicans
PMID28712894 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28712894/
RECORD: Rec_0069332 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 34.8%, E 0.0%, T 26.1%, C 39.1% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiparasitic Toxic Antimicrobial Antifungal Hemolytic Antitrypanosomal Antileishmanial
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0076187 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperLee I.H., Zhao C., Cho Y., Harwig S.S.L., Cooper E.L., Lehrer R.I.;. "Clavanins, alpha-helical antimicrobial peptides from tunicate hemocytes."; FEBS Lett. 400:158-162. Evidence URLhttps://www.uniprot.org/uniprotkb/CLVA_STYCL/entry
RECORD: Rec_0086689 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
80 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/10795591/ PMID10795591 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10795591/
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