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MYP_167854
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Basic Information
r8-BadBH3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
34 amino acids
C187H311N75O48S
Standard
Sequence
RRRRRRRRGNLWAAQRYGRELRRMSDEFVDSFKK
Physicochemical Analysis
4410.01 Da
12.00
9.76
9.55
0.2872
-1.90
0.92
-0.86
152.73
37.35
0.1176
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2130.32
-23.42
83.0
59.0
156.0
311.0
5.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0003399 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Anticancer
IMR5
50 μM
Concentration response
PaperBH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
RECORD: Rec_0006662 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
rrrrrrrr=D-isomer homopolymer of eight arginine residues
Bio-Activity Profile
Antimicrobial Anticancer
NGP (>50% apoptosis at 20 μM)
PaperPubMed PMID: 16568093 PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
RECORD: Rec_0012556 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Anticancer
SK-N-AS
20 μM
Concentration response
PaperBH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
RECORD: Rec_0043288 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
rrrrrrrr=D-isomer homopolymer of eight arginine residues
Bio-Activity Profile
Antimicrobial Anticancer
SK-N-AS (30% apoptosis at 50 μM)
PaperPubMed PMID: 16568093 PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
RECORD: Rec_0056343 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
rrrrrrrr=D-isomer homopolymer of eight arginine residues
Bio-Activity Profile
Antimicrobial Anticancer
IMR-5 (20% apoptosis at 20 μM)
PaperPubMed PMID: 16568093 PMID16568093 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16568093/
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